In NYC, Mills immediately formed a core of dancers to explore choreography. They incorporated in 2000 as the Tiffany Mills Company. To build work, Mills collaborates with contemporary composers, designers, and filmmakers. The Company's most recent projects include collaborations with: composers John Zorn and Ikue Mori; filmmaker Ela Troyano; performance artist Peter Petralia; and costume designer Naoko Nagata.

Called "one of the real talents of the emerging generation" by the Village Voice, and "Smart, fresh, and accomplished" by the New York Times, Mills' choreography has been produced at a variety of venues in NYC: Guggenheim Museum Works & Process, Duke Theater on 42 Street, Symphony Space Dance Sampler, Lincoln Center Out-of-Doors Series, Dancing in the Streets Dances for Wave Hill, Lower Manhattan Cultural Council Festival of Creative Communities, Tribeca Performing Arts Center, Joyce SoHo, Dance Theater Workshop Fresh Tracks, Danspace Project at St. Mark's Church DraftWork, Movement Research Judson Church, Performance Space 122 Avant-Garde-Arama, HERE, Dixon Place Words in Motion, and the 92nd Street Y Harkness Dance Center Sunday's at 3pm, among others.

Nationally, Mills has been presented as a National Performance Network Artist (07), and produced at: Portland Institute for Contemporary Art's Time Based Art Festival, OR; Wexner Center for the Arts, Columbus, OH; Contemporary Dance Theater, Columbus, OH; Jacob's Pillow Dance Festival, Lee, MA; The Dance Place, Washington D.C.; Bennington July Program, Bennington, VT; University Settlement Beacon Theater, Beacon, NY; Buckman Performing Arts Center, Memphis, TN; The Community Education Center, Philadelphia, PA; and Theater on Elm Street, Dallas, TX. Internationally, Mills has toured to: The First American Continents Contemporary Dance Competition, Mexico City, Mexico; and The Fringe Festival of Independent Dance Artists, Toronto, Canada. Mills has also worked as a choreographer for film, under the direction of Amos Kollek, starring Audrey Tautor (Happy End, 2002)

Mills teaches regularly as a guest artist at the Trisha Brown Studios, NYC, and at Conduit, Inc, Portland, OR. She currently guest teaches composition through Pentacle at Frank Sinatra High School of the Performing Arts (2007-08), and has taught as a faculty member at Trinity/LaMama, an experimental performance program, NYC (2001-05). Additionally, Mills has taught as a guest artist at: American Dance Festival/Winter Intensive, American College Dance Festival (teacher and adjudicator), University of Oregon, Ohio State University, Ohio University, Muhlenberg College, Goucher College, Kenyon College, James Madison University, University of Memphis, Roger Williams University, Trinity College, New World School of the Arts, Slippery Rock University, and Presbyterian College.

The Company has received funding from: American Music Center, Bogliasco Foundation, Brooklyn Arts Council/JP Morgan Chase, Evelyn Sharp Foundation, Fund for Creative Communities, Harkness Foundation, Jerome Robbins Foundation, Manhattan Community Arts Fund, Meet the Composer, New York City Department of Cultural Affairs Cultural Challenge Program, Puffin Foundation, and Sorin Charitable Trust.